李梦倩;李涛;刘肇瑞;黄悦勤;方楚楚;张鑫;陈红光;张婷婷;马超;

• 1:南昌大学第一附属医院心身医学科
• 2:北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院)

摘要(Abstract)：

目的:系统评价认知促进治疗(CST)对老年性痴呆患者的治疗效果,为临床实践提供依据。方法:检索外文数据库PubMed、Embase、Cochrane library及中文数据库知网、维普和万方数据库中建库至2019年6月间采用随机对照研究(RCT)设计的CST对于老年性痴呆患者治疗效果的文献,采用Cochrane风险偏倚评估工具进行文献质量评价后,使用ReVMan5.3软件进行meta分析。结果:共纳入9篇研究,合计样本量684人。2篇文献仅以阿尔茨海默病评估量表-认知分表(ADAS-Cog)评分为效果评价指标,3篇文献仅以简易智力状态检查量表(MMSE)评分为效果评价指标,其余4篇采用了上述两种评价指标。以ADAS-Cog评分为效果评价指标的meta分析结果显示,CST与对照组均显示有改善效果,但差异无统计学意义(SMD=0.02,Z=0.22,P>0.05)。以MMSE评分为效果评价指标的meta分析结果显示,CST对老年性痴呆的认知功能改善优于对照组(SMD=0.47,Z=2.73,P<0.01)。结论:CST可以在一定程度上改善老年性痴呆患者的认知功能,但需要在大样本研究以及发展中国家中进一步验证。

关键词(KeyWords)： 痴呆;认知促进治疗;随机对照试验;meta分析

Abstract:

Keywords:

基金项目(Foundation): 首都临床特色应用研究与成果推广(Z171100001017119);; 首都卫生发展科研专项(首发2011-4024-05,首发2020-2Z-4116)

作者(Author): 李梦倩;李涛;刘肇瑞;黄悦勤;方楚楚;张鑫;陈红光;张婷婷;马超;

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DOI:

参考文献(References)：

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