孤独症谱系障碍儿童心理推理能力与局部脑功能连接的关系Relationship between theory of mind and local brain functional connectivity children with autism spectrum disorder
尹婷妮;李雪;王慧;李慧娴;吉兆正;宫小云;汤欣舟;阳雨露;刘勤一;赵荔阳;严超赣;刘靖;
摘要(Abstract):
目的:探讨孤独症谱系障碍(ASD)儿童心理推理能力(ToM)与局部脑功能连接的关系。方法:选取符合DSM-5诊断标准的6~18岁ASD儿童39例和年龄、性别及智商相匹配的正常儿童43例,进行ToM任务测查和静息态磁共振成像扫描,比较两组ToM通过率/得分和全脑局部一致性(ReHo)缺陷的脑机制值,并采用偏相关方法分析两组间存在差异的ToM通过率/得分和ReHo值之间的关系。结果:ASD组显性错误信念、一级错误信念通过率和表情识别任务得分低于正常对照组(均P<0.05);右额上回局部ReHo值高于正常对照组,右距状沟、左内侧额叶皮层区域ReHo值低于正常对照组(GRF校正,体素P<0.001,团块P<0.05);显性错误信念通过率与左内侧额叶皮层局部ReHo值呈负相关(r=-0.46,P<0.05)。结论:ASD患者存在ToM缺陷和局部一致性异常,其中显性错误信念与左内侧额叶皮层局部功能连接相关。
关键词(KeyWords): 孤独症谱系障碍;心理推理能力;局部一致性;内侧额叶皮层
基金项目(Foundation): 国家重点研发计划资助(2017YFC1309900);; 国家自然科学基金(81271508);国家自然科学基金(81571339);; 北京市自然科学基金(7164314)
作者(Authors): 尹婷妮;李雪;王慧;李慧娴;吉兆正;宫小云;汤欣舟;阳雨露;刘勤一;赵荔阳;严超赣;刘靖;
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