尹婷妮;李雪;王慧;李慧娴;吉兆正;宫小云;汤欣舟;阳雨露;刘勤一;赵荔阳;严超赣;刘靖;

• 1:北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院)
• 2:中国科学院心理研究所行为科学重点实验室中国科学院大学心理学系中国科学院心理研究所磁共振成像研究中心

摘要(Abstract)：

目的:探讨孤独症谱系障碍(ASD)儿童心理推理能力(ToM)与局部脑功能连接的关系。方法:选取符合DSM-5诊断标准的6～18岁ASD儿童39例和年龄、性别及智商相匹配的正常儿童43例,进行ToM任务测查和静息态磁共振成像扫描,比较两组ToM通过率/得分和全脑局部一致性(ReHo)缺陷的脑机制值,并采用偏相关方法分析两组间存在差异的ToM通过率/得分和ReHo值之间的关系。结果:ASD组显性错误信念、一级错误信念通过率和表情识别任务得分低于正常对照组(均P<0.05);右额上回局部ReHo值高于正常对照组,右距状沟、左内侧额叶皮层区域ReHo值低于正常对照组(GRF校正,体素P<0.001,团块P<0.05);显性错误信念通过率与左内侧额叶皮层局部ReHo值呈负相关(r=-0.46,P<0.05)。结论:ASD患者存在ToM缺陷和局部一致性异常,其中显性错误信念与左内侧额叶皮层局部功能连接相关。

关键词(KeyWords)： 孤独症谱系障碍;心理推理能力;局部一致性;内侧额叶皮层

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划资助(2017YFC1309900);; 国家自然科学基金(81271508);国家自然科学基金(81571339);; 北京市自然科学基金(7164314)

作者(Author): 尹婷妮;李雪;王慧;李慧娴;吉兆正;宫小云;汤欣舟;阳雨露;刘勤一;赵荔阳;严超赣;刘靖;

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