马增慧;曹庆久;严超赣;梅婷;鲁彬;刘静然;杨柳;王慧;汤欣舟;吉兆正;徐凌子;阳雨露;李雪;刘靖;

• 1:北京大学第六医院
• 2:北京大学精神卫生研究所
• 3:国家卫生健康委员会精神卫生学重点实验室(北京大学)
• 4:国家精神心理疾病临床医学研究中心(北京大学第六医院)

摘要(Abstract)：

目的:探讨6～18岁高功能孤独症患者执行网络功能连接特点、年龄组差别及与孤独症症状的相关。方法:纳入44例6～18岁符合DSM-IV孤独症诊断标准的高功能患者及年龄、性别、智商组间匹配的31例正常对照,根据年龄将每组被试分为儿童期(6～12岁)和青春期(12～18岁)两组。选取左右侧后顶叶皮层及背外侧前额叶4个执行网络的核心脑区为种子点,计算其与全脑的功能连接。采用偏相关分析计算异常脑区功能连接与孤独症谱系障碍筛查问卷评分的相关。结果:孤独症组rdl PFC与左侧额上回/额中回/前扣带回的功能连接高于正常对照组(P <0. 05),该脑区功能连接同时呈现组别-年龄交互效应,在儿童期孤独症组高于正常对照组,在青春期低于正常对照组(均P <0. 05)。且该异常功能连接与重复刻板行为及交流问题呈负相关(r=-0. 50～-0. 45)(均P <0. 05)。结论:6～18岁高功能孤独症患者的执行网络存在过度连接特点及年龄组别差异,与重复刻板及交流症状相关。

关键词(KeyWords)： 孤独症;功能连接;执行功能;背外侧前额叶;前扣带回

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81271508);国家自然科学基金(81571339);; 北京市自然科学基金(7164314)

作者(Authors): 马增慧;曹庆久;严超赣;梅婷;鲁彬;刘静然;杨柳;王慧;汤欣舟;吉兆正;徐凌子;阳雨露;李雪;刘靖;

参考文献(References)：

• [1]M urray M J.Attention-deficit/Hyperactivity Disorder in the context of Autism spectrum disorders[J].Curr Psychiatry Rep,2010,12(5):382-388.
• [2]Hill EL.Evaluating the theory of executive dysfunction in autism[J].Dev Rev,2004,24(2):189-233.
• [3]Demetriou EA,Lampit A,Quintana DS,et al.Autism spectrum disorders:a meta-analysis of executive function[J].M ol Psychiatry,2018,23(5):1198-1204.
• [4]Seeley WW,M enon V,Schatzberg AF,et al.Dissociable intrinsic connectivity netw orks for salience processing and executive control[J].J Neurosci,2007,27(9):2349-2356.
• [5]Solomon M,Yoon JH,Ragland JD,et al.The development of the neural substrates of cognitive control in adolescents w ith autism spectrum disorders[J].Biol Psychiatry,2014,76(5):412-421.
• [6]Anderson JS,Nielsen JA,Froehlich AL,et al.Functional connectivity magnetic resonance imaging classification of autism[J].Brain,2011,134(Pt 12):3742-3754.
• [7]黄悦勤.医学科研中随机误差控制和样本量确定[J].中国心理卫生杂志,2015,29(11):874-880.
• [8]American Psychiatric Association.Diagnostic and statistical manual of mental disorders(DSM-IV)[M].4th ed.Washington.DC:A-merican Psychiatric Publishing Inc,1994.
• [9]龚耀先,蔡太生.中国修订韦氏儿童智力量表[J].中国临床心理学杂志,1994,(1):1-6.
• [10]修订韦氏成人智力量表全国协作组.韦氏成人智力量表的修订[J].心理学报,1983,(3):362-370.
• [11]Kaufman J,Birmaher B,Brent D,et al.Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version(K-SADS-PL):initial reliability and validity data[J].J Am Acad Child Adolesc Psychiatry,1997,36(7):980-988.
• [12]Guo YQ,Tang Y,Rice C,et al.Validation of the Autism Spectrum Screening Questionnaire,M andarin Chinese Version(CH-ASSQ)in Beijing,China[J].Autism,2011,15(6):713-727.
• [13]Yan CG,Zang YF.DPARSF:A M ATLAB Toolbox for"Pipeline"data analysis of resting-state fM RI[J].Front Syst Neurosci,2010,4:13.
• [14]Yan CG,Wang XD,Zuo XN,et al.DPABI:Data processing&analysis for(resting-state)brain imaging[J].Neuroinformatics,2016,14(3):339-351.
• [15]Zheng H,Xu L,Xie F,et al.The altered triple netw orks interaction in depression under resting state based on graph theory[J].BioM ed Res Int,2015,2015:386326.doi:10.1155/2015/386326.
• [16]Solomon M,Ragland JD,Niendam TA,et al.Atypical learning in autism spectrum disorders:a functional magnetic resonance imaging study of transitive inference[J].J Am Acad Child Adolesc Psychiatry,2015,54(11):947-955.
• [17]Yerys BE,Antezana L,Weinblatt R,et al.Neural correlates of setshifting in children w ith autism[J].Autism Res,2015,8(4):386-397.
• [18]Curtis CE.Prefrontal and parietal contributions to spatial w orking memory[J].Neuroscience,2006,139(1):173-180.
• [19]Silton RL,Heller W,Tow ers DN,et al.The time course of activity in dorsolateral prefrontal cortex and anterior cingulate cortex during top-dow n attentional control[J].NeuroImage,2010,50(3):1292-1302.
• [20]Spielberg JM,M iller GA,Heller W,et al.Flexible brain netw ork reconfiguration supporting inhibitory control[J].Proc Natl Acad Sci U S A,2015,112(32):10020-10025.
• [21]Supekar K,Uddin LQ,Khouzam A,et al.Brain hyperconnectivity in children w ith autism and its links to social deficits[J].Cell Rep,2013,5(3):738-747.
• [22]Just M A,Keller TA,M alave VL,et al.Autism as a neural systems disorder:a theory of frontal-posterior underconnectivity[J].Neurosci Biobehav Rev,2012,36(4):1292-1313.
• [23]D'Cruz AM,Ragozzino M E,M osconi M W,et al.Reduced behavioral flexibility in autism spectrum disorders[J].Neuropsychology,2013,27(2):152-160.
• [24]李雪,刘靖,杨文,等.高功能孤独症儿童执行功能和心理推理能力特点及临床症状[J].中国心理卫生杂志,2012,26(8):584-589.