胡霄;黄颐;

• 1:四川大学华西医院心理卫生中心

摘要(Abstract)：

镜像神经元假说被认为是一种较全面地解释孤独症谱系障碍的临床症状和神经生物学异常的神经-认知理论。本文综述了国内外近年来在孤独症谱系障碍中镜像神经元功能的研究,分别探讨了神经电生理、神经影像学,神经心理学等方面研究结果,提示这些患者存在部分的镜像神经元功能损害,这些损害与孤独症谱系障碍患者其他的神经认知和社会认知功能损害有着密切关系。

关键词(KeyWords)： 孤独症谱系障碍;镜像神经元;综述

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(项目编号:81371495)

作者(Authors): 胡霄;黄颐;

参考文献(References)：

• [1]Tchaconas A,Adesman A.Autism spectrum disorders[J].Curr Opin Pediatr,2013,25(1):130-144.
• [2]Taylor E,Rutter M,Bishop D,et al.Rutter's child and adolescent psychiatry[M].5th ed.Oxford:Wiley-Blackwell,2008:18-31.
• [3]李咏梅,邹小兵.孤独症认知理论研究概况[J].中国儿童保健杂志,2006,14(2):169-171.
• [4]Betancur C.Etiological heterogeneity in autism spectrum disorders:more than 100 genetic and genomic disorders and still counting[J].Brain Res,2011,1380(3):42-77.
• [5]di Pellegrino G,Fadiga L,Fogassi L,et al.Understanding motor events:a neurophysiological study[J].Exp Brain Res,1992,91(1):176-180.
• [6]Gallese V,Fadiga L,Fogassi L,et al.Action recognition in the premotorcortex[J].Brain,1996,119(Pt 2):593-609.
• [7]Pineda JA.Sensorimotor cortex as a critical component of an'extended'mirror neuron system:does it solve the development,correspondence,and control problems in mirroring?[J].Behav Brain Funct,2008,4:47.doi:10.1186/1744-9081-4-47.
• [8]Rizzolatti G,Craighero L.The mirror neuron-system[J].Ann Rev Neurosci,2004,27(1):169-192.
• [9]Fogassi L,Ferrari PF.Mirror neurons and the evolution of embodied language[J].Curr Direct Psychol Sci,2007,16(31):36-41.
• [10]Buccino G,Vogt S,Ritzl A,et al.Neural circuits underlying imitation learning of hand actions:an event-related f MRI Study[J].Neuron,2004,42(2):323-334.
• [11]Williams JH,Whiten A,Singh T.A Systematic reviewof action imitation in autistic spectrum disorder[J].J Autism Dev Disord,2004,34(3):285-299.
• [12]Dapretto M,Davies MS,Pfeifer JH,et al.Understanding emotions in others:mirror neuron dysfunction in children with autism spectrum disorders[J].Nat Neurosci,2006,9(1):28-30.
• [13]Oberman LM,Ramachandran VS.The simulating social mind:the role of the mirror neuron system and simulation in the social and communicative deficits of autism spectrum disorders[J].Psychol Bull,2007,133(2):310-327.
• [14]Bonini L,Ferrari PF,Fogassi L.Neurophysiological bases underlying the organization of intentional actions and the understanding of others'intention[J].Conscious Cogn,2013,22(3):1095-1104.
• [15]Rizzolatti G,Fabbri-destro M,Cattaneo L.Mirror neurons and their clinical relevance[J].Nat Clin Pract Neurol,2009,5(1):24-34.
• [16]Oberman LM,Hubbard EM,Mc Cleery JP,et al.EEG evidence for mirror neuron dysfunction in autism spectrum Disorders[J].Brain Res Cogn Brain Res,2005,24(2):190-198.
• [17]Oberman LM,Ramachandran VS,Pineda JA.Modulation of mu suppression in children with autism spectrum disorders in response to familiar or unfamiliar stimuli:the mirror neuron hypothesis[J]Neuropsychologia,2005,46(5):1558-1565.
• [18]Raymaekers R,Wiersema JR,Roeyers H.EEG study of the mirror neuron system in children with high functioning autism[J].Brain Res,2009,1304:113-121.
• [19]Oberman LM,Mc Cleery JP,Hubbard EM,et al.Developmental changes in mu suppression to observed and executed actions in autism spectrum disorders[J].Soc Cogn Affect Neurosci,2013,8(3):300-304.
• [20]Honaga E,Ishii R,Kurimoto R,et al.Post-movement beta rebound abnormality as indicator of mirror neuron system dysfunction in autistic spectrum disorder:an MEG study[J].Neurosci Lett,2010,478(3):141-145.
• [21]Puzzo I,Cooper NR,Vetter P,et al.Reduced cortico-motor facilitation in a normal sample with high traits of autism[J].Neurosci Lett,2009,467(2):173-177.
• [22]Théoret H,Halligan E,Kobayashi M,et al.Impaired motor facilitation during action observation in individuals with autism spectrum disorder[J].Curr Biol,2005,15(3):R84-85.
• [23]Enticott PG,Kennedy HA,Rinehart NJ,et al.Mirror neuron activity associated with social impairments but not age in autism spectrum disorder[J].Biol Psychiatry,2012,71(5):427-433.
• [24]Fitzgerald PB,Fountain S,Daskalakis ZJ.A comprehensive reviewof the effects of TMS on motor cortical excitability and inhibition[J].Clin Neurophysiol,2006,117(12):2584-2596.
• [25]Dapretto M,Iacoboni M.The mirror neuron system and the consequences of its Dysfunction[J].Nat Rev Neurosci,2006,7(12):942-951.
• [26]Grèzes J,Wicker B,Berthoz S,et al.A failure to grasp the affective meaning of actions in autism spectrum disorder subjects[J].Neuropsychologia,2009,47(8-9):1816-1825.
• [27]Bastiaansen JA,Thioux M,Nanetti L,et al.Age-related increase in inferior frontal gyrus activity and social functioning in autism spectrum disorder[J].Biol Psychiatry,2011,69(9):832-838.
• [28]Schulte-Rüther M,Greimel E,Markowitsch HJ,et al.Dysfunctions in brain networks supporting empathy:an f MRI study in adults with autism spectrum disorders[J].Soc Neurosci,2011,6(1):1-21.
• [29]Fishman I,Keown CL,Lincoln AJ,et al.Atypical cross talk between mentalizing and mirror neuron networks in autism spectrum disorder[J].JAMA Psychiatry,2014,71(7):751-760.
• [30]Yamasaki S,Yamasue H,Abe O,et al.Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders[J].Biol Psychiatry,2010,68(12):1141-1147.
• [31]Hadjikhani N,Joseph RM,Snyder J,et al.Anatomical differences in the mirror neuron system and social cognition network in autism[J].Cereb Cortex,2006,16(9):1276-1282.
• [32]Duerden EG,Mak-Fan KM,Taylor MJ,et al.Regional differences in grey and white matter in children and adults with autism spectrum disorders:an activation likelihood estimate(ALE)meta-analysis[J].Autism Res,2012,5(1):49-66.
• [33]Brambilla P,Hardan A,di Nemi SU,et al.Brain anatomy and development in autism:reviewof structural MRI studies[J].Brain Res Bull,2003,61(6):557-569.
• [34]Kana RK,Wadsworth HM,Travers BG.A systems level analysis of the mirror neuron hypothesis and imitation impairments in autism spectrum disorders[J].Neurosci Biobehav Rev,2011,35(3):894-902.
• [35]Pelphrey KA,Yang DY,Mc Partland JC.Building a social neuroscience of autism spectrum disorder[J].Curr Top Behav Neurosci,2014,16(7):215-233.
• [36]Corbetta M,Shulman GL.Control of goal directed and stimulus driven attention in the brain[J].Nat Rev Neurosci,2002,3(3):201-215.
• [37]Singh-Curry V,Husain M.The functional role of the inferior parietal lobe in the dorsal and ventral stream dichotomy[J].Neuropsychologia,2009,47(6):1434-1448.
• [38]Pelphrey KA,Morris JP,Mc Carthy G.Neural basis of eye gaze processing deficits in autism[J].Brain,2005,128(5):1038-1048.
• [39]Williams JH.Self-other relations in social development and autism:multiple roles for mirror neurons and other brain bases[J].Autism Res.2008,1(2):73-90.
• [40]Bernier R,Aaronson B,Mc Partland J.The role of imitation in the observed heterogeneity in EEG mu rhythm in autism and typical development[J].Brain Cogn,2013,82(1):69-75.
• [41]Wang Y,Hamilton AF.Social top-down response modulation(STORM):a model of the control of mimicry in social interaction[J].Front Hum Neurosci,2012,153(6):1-10.
• [42]李晶,林珠梅,朱莉琪.孤独症谱系障碍的遗传基础与神经机制[J].生物化学与生物物理进展,2012,39(10):952-961.